abstract：:Some polymorphisms in genes codifying for fibrinogen have been correlated with plasma levels of this protein, and several studies reported their associations with acute cardiovascular events. In the present study, 118 subjects with unstable and stable coronary diseases were enrolled to determinate the associations amo...

journal_title：Disease markers

authors： Canseco-Avila LM,Lopez-Roblero A,Serrano-Guzman E,Aguilar-Fuentes J,Jerjes-Sanchez C,Rojas-Martinez A,Ortiz-Lopez R

更新日期：2019-07-01 00:00:00

abstract：:Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the lig...

journal_title：Disease markers

authors： Ouyang Q,You T,Guo J,Xu R,Guo Q,Lin J,Zhao H

更新日期：2019-06-17 00:00:00

abstract：Objective:To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods:Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the qu...

journal_title：Disease markers

authors： Liu Z,Shi H

更新日期：2019-06-02 00:00:00

abstract：Background:With the development of new drug combinations and targeted treatments for multiple types of cancer, the ability to stratify categories of patient populations and to develop companion diagnostics has become increasingly important. A panel of 325 RNA biomarkers was selected based on cancer-related biological p...

journal_title：Disease markers

authors： Delmonico L,Attiya S,Chen JW,Obenauer JC,Goodwin EC,Fournier MV

更新日期：2019-05-14 00:00:00

abstract：:A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...

journal_title：Disease markers

authors： Kułak-Bejda A,Waszkiewicz N,Bejda G,Zalewska A,Maciejczyk M

更新日期：2019-05-02 00:00:00

abstract：Background:Syndecan-1 (SDC1/CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and the interactions with the surrounding microenvironment. SDC1 tumor immunoexpression may be increased or decreased in epithelial malignant neoplasms compared to that in adjacent non-neoplastic tissue,...

journal_title：Disease markers

authors： Li K,Li L,Wu X,Yu J,Ma H,Zhang R,Li Y,Wang W

更新日期：2019-04-30 00:00:00

abstract：:The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryng...

journal_title：Disease markers

authors： Matulka M,Konopka A,Mroczko B,Pryczynicz A,Kemona A,Groblewska M,Sieskiewicz A,Olszewska E

更新日期：2019-04-18 00:00:00

abstract：Background:The role of miR-200c in gastric cancer remains controversial. This study is aimed at clarifying the diagnostic and prognostic value of miR-200c in gastric cancer through a meta-analysis. Methods:A comprehensive literature search of PubMed, Embase, and Ovid library databases was conducted. The studies includ...

journal_title：Disease markers

authors： Huang ZS,Guo XW,Zhang G,Liang LX,Nong B

更新日期：2019-04-04 00:00:00

abstract：:Colorectal cancer (CRC) is a complex and heterogeneous disease with four consensus molecular subtypes (CMS1-4). LTBP2 is a member of the fibrillin/LTBP super family and plays a critical role in tumorigenesis by activating TGF-β in the CMS4 CRC subtype. So far, the expression and prognostic significance of LTBP2 in CRC...

journal_title：Disease markers

authors： Huang Y,Wang G,Zhao C,Geng R,Zhang S,Wang W,Chen J,Liu H,Wang X

更新日期：2019-03-10 00:00:00

abstract：:RARβ plays a critical role in cancer progression and is associated with several types of human cancer. It remains unclear, however, whether it is linked to the clinicopathological parameters of colorectal cancer (CRC). We therefore determined the expression of RARβ protein in patients with primary CRC and examined its...

journal_title：Disease markers

authors： Wang W,Liu S,Jiang C,Wang Y,Zhu H,Wang X

更新日期：2019-03-03 00:00:00

abstract：:Because tandem mass spectrometry- (MS/MS-) based newborn screening identifies many suspicious cases of fatty acid oxidation and carnitine cycle disorders, a simple, noninvasive test is required to confirm the diagnosis. We have developed a novel method to evaluate the metabolic defects in peripheral blood mononuclear ...

journal_title：Disease markers

authors： Yuasa M,Hata I,Sugihara K,Isozaki Y,Ohshima Y,Hara K,Tajima G,Shigematsu Y

更新日期：2019-02-07 00:00:00

abstract：Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...

journal_title：Disease markers

authors： Kamieniak P,Bielewicz J,Grochowski C,Litak J,Bojarska-Junak A,Daniluk B,Trojanowski T

更新日期：2019-01-14 00:00:00

abstract：:Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expr...

journal_title：Disease markers

authors： Wang X,Ning Y,Zhang P,Yang L,Li C,Zhou R,Guo X

更新日期：2019-01-03 00:00:00

abstract：Background:Preeclamptic pregnancies often present an intensified inflammatory state associated with the nuclear activity of NFκB. NEMO is an essential regulator of nuclear factor kappa B (NFκB) in cytoplasmic and nuclear cellular compartments. The aim of the present study is to examine the level and localization of the...

journal_title：Disease markers

authors： Sakowicz A,Lisowska M,Biesiada L,Płuciennik E,Gach A,Rybak-Krzyszkowska M,Huras H,Sakowicz B,Romanowicz H,Piastowska-Ciesielska AW,Grzesiak M,Pietrucha T

更新日期：2019-01-02 00:00:00

abstract：Background:Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by asses...

journal_title：Disease markers

authors： Khadir A,Kavalakatt S,Dehbi M,Alarouj M,Bennakhi A,Tiss A,Elkum N

更新日期：2018-12-13 00:00:00

abstract：Background:The systemic immune-inflammation index (SII), based on peripheral lymphocytes, neutrophils, and platelet count, has been used as a prognostic marker for several tumors. However, use of the SII has not been reported for gastric cancer. Methods:We evaluated the prognostic value of the SII in primary and valid...

journal_title：Disease markers

authors： Shi H,Jiang Y,Cao H,Zhu H,Chen B,Ji W

更新日期：2018-12-02 00:00:00

abstract：Purpose:Modern neuroimaging techniques allow investigating brain structures and substances involved in the pathophysiology of mental disorders, trying to find new markers of these disorders. To better understanding of the pathophysiology and differential diagnosis of schizophrenia and bipolar disorder, this study was c...

journal_title：Disease markers

authors： Galińska-Skok B,Małus A,Konarzewska B,Rogowska-Zach A,Milewski R,Tarasów E,Szulc A,Waszkiewicz N

更新日期：2018-11-25 00:00:00

abstract：Aims:The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods:A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n = 237) diagnosed with acute pancreatitis ...

journal_title：Disease markers

authors： Chai X,Huang HB,Feng G,Cao YH,Cheng QS,Li SH,He CY,Lu WH,Qin MM

更新日期：2018-11-19 00:00:00

abstract：Objectives:Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin and α1-antitrypsin were both inflammation-related molecules. The present study investigat...

journal_title：Disease markers

authors： Koshi R,Kotani K,Ohtsu M,Yoshinuma N,Sugano N

更新日期：2018-11-07 00:00:00

abstract：Aim:To explore the diagnostic efficacy of des-gamma-carboxy prothrombin (DCP) in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). Methods:A retrospective study of 459 cases from June 2016 to March 2018 was undertaken, and records of the DCP levels were extracted. The sensitivity, specificity, and cuto...

journal_title：Disease markers

authors： Chen J,Wu G,Li Y

更新日期：2018-10-04 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their ca...

journal_title：Disease markers

authors： Cassani R,Estarellas M,San-Martin R,Fraga FJ,Falk TH

更新日期：2018-10-04 00:00:00

abstract：Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...

journal_title：Disease markers

authors： Wang P,Li C,Zhang F,Ma X,Gai X

更新日期：2018-09-27 00:00:00

abstract：:In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bla...

journal_title：Disease markers

authors： Liu GM,Xu ZQ,Ma HS

更新日期：2018-09-19 00:00:00

abstract：:The clinical distinction of frontotemporal dementia (FTD) and Alzheimer's disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive im...

journal_title：Disease markers

authors： Nardone R,Sebastianelli L,Versace V,Saltuari L,Lochner P,Frey V,Golaszewski S,Brigo F,Trinka E,Höller Y

更新日期：2018-09-03 00:00:00

abstract：Background and Objective:Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, ...

journal_title：Disease markers

authors： Brito-Mendoza L,Bologna-Molina R,Irigoyen-Camacho ME,Martinez G,Sánchez-Romero C,Mosqueda-Taylor A

更新日期：2018-07-29 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/2138627.]. ...

journal_title：Disease markers

authors： Marrugal Á,Ojeda L,Paz-Ares L,Molina-Pinelo S,Ferrer I

更新日期：2018-07-08 00:00:00

abstract：Background:Determination of neonate serum's N-acetyl-β-hexosaminidase (HEX) activity and correlation results with Apgar scale and factors routinely determined in newborn serum. Aims:Providing reference values of neonates serum HEX activities, and indicate their diagnostic significance. Study design:The study was perf...

journal_title：Disease markers

authors： Chojnowska S,Kamianowska M,Baran P,Zwierz K,Szczepański M

更新日期：2018-07-02 00:00:00

abstract：Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...

journal_title：Disease markers

authors： Su Q,Yang H,Li L

更新日期：2018-06-25 00:00:00

abstract：Background:Analysis of the correlation between diabetes type 2 (DT2) and serum N-acetyl-β-hexosaminidase (HEX) activity with parameters of fat metabolism and symptoms of anxiety and depression. Material and Method:The study was performed using a random sample of 40 DT2 patients (22 women and 18 men) between the ages o...

journal_title：Disease markers

authors： Chojnowska S,Cabaj-Wiater I,Mikulska-Baran A,Zalewska-Szajda B,Waszkiewicz N

更新日期：2018-06-20 00:00:00

abstract：:The nonspecific inflammatory bowel diseases (IBD) represent a heterogeneous group of chronic inflammatory disorders of the gastrointestinal tract, and Leśniowski-Crohn's disease (CD) and ulcerative colitis (UC) are among the two major clinical forms. Despite the great progress in understanding the pathogenesis of thes...

journal_title：Disease markers

authors： Derkacz A,Olczyk P,Komosinska-Vassev K

更新日期：2018-06-11 00:00:00

abstract：Background:It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods:PubMed, Scopus, Web of Science, Chinese Nati...

journal_title：Disease markers

authors： Sun X,Zhou X,Zhang Y,Zhu X,Liu H

更新日期：2018-05-15 00:00:00

abstract：Objective:This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods:A cross-sectional study including 180 type 2 diabetic participants was conducted...

journal_title：Disease markers

authors： Feng L,Deng C,Li Y

更新日期：2018-04-16 00:00:00

abstract：Objective:To evaluate the performance of serum and urinary sCD163 concentrations as possible biomarker in systemic sclerosis (SSc). Methods:Urine and serum samples were obtained from SSc patients and age- and sex-matched controls. Serum and urinary sCD163 concentrations were measured by commercially available ELISA ki...

journal_title：Disease markers

authors： Frantz C,Pezet S,Avouac J,Allanore Y

更新日期：2018-04-01 00:00:00

abstract：:Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...

journal_title：Disease markers

authors： Xia X,He C,Wu A,Zhou J,Wu J

更新日期：2018-03-18 00:00:00

abstract：:We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing o...

journal_title：Disease markers

authors： Chen Y,Lu Y,Kuyaxi P,Cheng J,Zhao J,Zhao Q,Musha P,Zhang H,Yuan H

更新日期：2018-03-05 00:00:00

abstract：:Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxi...

journal_title：Disease markers

authors： Martynova EV,Maksudova AN,Shakirova VG,Abdulkhakov SR,Khaertynova IM,Anokhin VA,Ivanova VV,Abiola IM,Garanina EE,Tazetdinova LG,Valiullina AH,Khaiboullina SF

更新日期：2018-02-26 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associa...

journal_title：Disease markers

authors： Ferreira RR,Madeira FDS,Alves GF,Chambela MDC,Curvo EOV,Moreira ADS,Almeida de Sá R,Mendonça-Lima L,Cabello PH,Bailly S,Feige JJ,Araujo-Jorge TC,Saraiva RM,Waghabi MC

更新日期：2018-02-18 00:00:00

abstract：Background:In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG...

journal_title：Disease markers

authors： Morawiec B,Kawecki D,Przywara-Chowaniec B,Opara M,Muzyk P,Ho L,Tat LC,Gabrysiak A,Muller O,Nowalany-Kozielska E

更新日期：2018-01-24 00:00:00

abstract：BACKGROUND:Lymph node (LN) metastasis was an independent risk factor for stomach cancer recurrence, and the presence of LN metastasis has great influence on the overall survival of stomach cancer patients. Thus, accurate prediction of the presence of lymph node metastasis can provide guarantee of credible prognosis eva...

journal_title：Disease markers

authors： Wu J,Xiao Y,Xia C,Yang F,Li H,Shao Z,Lin Z,Zhao X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. METHODS...

journal_title：Disease markers

authors： Meng XY,Shi MJ,Chen JF,Liao Y,Hu BW,Hireche A

更新日期：2017-01-01 00:00:00